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Disruption of human APC in colonic epithelia initiates benign polyps that progress to carcinoma following additional mutations.
Our understanding of the evolution, formation, and pathological disruption of human brain circuits is impeded by a lack of comprehensive data on the developing brain transcriptome.
The incorporation of local traditions, such as myths recalling precedents in particular areas, could make a significant difference to the degree of community acceptance of adaptation strategies [75, 76], particularly as the disruption of human livelihoods along Asia-Pacific coasts becomes more widespread as sea level rises over the next few decades and beyond [83].
The existence of several human congenital syndromes caused by disruption of human TBX genes, demonstrates their importance in morphogenesis.
The fact that the isolated HOXA9 moiety (HOXA9ΔN) had no effect on differentiation shows that the NUP98 moiety is necessary for disruption of human hematopoietic differentiation.
Similar work by Muhlhausen and colleagues showed disruption of human derived endothelial cells exposed to 3-OH-glutaric acid [ 35].
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Permafrost degradation results in thaw settlement of the ground surface, most likely resulting in the disruption of human-made infrastructure, which is especially true for ice-rich permafrost regions.
With efficient contact tracing, the window of time during which an infected symptomatic person can transmit the disease is minimized, allowing for rapid disruption of human-to-human transmission.
Mounting research evidence demonstrates a significant negative impact of circadian disruption on human health.
Other mechanisms, such as impact of sleep disruption on human physiological processes, may also be involved [ 30], although not all the results of studies on the impact of sleep disruption on breast cancer risk have been consistent [ 31, 32].
This model's success enables further study into causal pathways by which endocrine-disrupting and endocrine-mimicking substances may directly cause disruption of normal human urethral development or hypospadias.
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