Sentence examples for disruption of gene from inspiring English sources
All four mutations found in strain FSC043 have caused disruption of gene functions: all of the disrupted genes in the strain FSC043 have been linked to virulence or have orthologs in F. novicida that have been linked to virulence.
One mechanism is through disruption of gene function: microsatellite expansions residing in exon or intron sequences disrupt the normal function of the gene product.
The basic premise in these is that, the inability of the bacterium to survive due to the disruption of gene expression by the inserted transposon indicates essentiality of the disrupted gene.
NHEJ may introduce indels that cause frame shift mutations and hence the disruption of gene functions.
Developing technologies for efficient and scalable disruption of gene expression will provide powerful tools for studying gene function, developmental pathways, and disease mechanisms.
Loss-of-function (LOF) (i.e., nonsense, splice site, and frameshift) variants that lead to disruption of gene function are likely to contribute to the etiology of neuropsychiatric disorders.
PWS arises from the deletion or disruption of genes in a particular region of chromosome 15.
Overall, these observations provide a roadmap for a 'human knockout project', a systematic effort to understand the phenotypic consequences of complete disruption of genes in humans.
Because RRN10 is a non-essential gene, this success prompted us to isolate suppressor mutants of disruption of genes encoding essential UAF components, such as RRN5.
However, in strain NZN111, the inactivation of LDH and PFL due to the disruption of genes ldhA and pflB, respectively, blocked the two alternate pathways and failed to regenerate sufficient NAD+ to oxidize glucose under anaerobic conditions.
The results of phenotypic analysis suggest that LSE2 and LSE3 mutations are caused by the disruption of genes involved in the path of sucrose transport from mesophyll cells to phloem sieve elements in rice leaves.
