Understanding molecular mechanisms of toxicity is facilitated by experimental manipulations, such as disruption of function by gene targeting, that are especially challenging in non-standard model species with limited genomic resources.
The biology of adolescence is distinctive and provides opportunities for unique actions of toxicants both in terms of disruption of function and disruption of maturation.
Does this mean that a single point mutation can be disfavored for a minor disruption of function?
Second, that SL interactions, which are defined between two genes when disruption of function of either gene product is viable but disruption of function of both simultaneously results in death, could be screened in genetically amenable model organisms to identify those that may be relevant to the treatment of tumors (Hartwell et al. 1997).
Genes with multiple PPIs have a higher probability to be essential, just because the deletions of these genes may result in the disruption of function of a larger number of proteins [ 28- 30].
Disruption of function for PFB0106c, MAL7P1.172, PF14_0758, and PF13_0076 resulted in a complete lack or greatly reduced levels of PfEMP1 on the parasite-infected erythrocyte suggesting they are required for subcellular localization of this virulence protein.
Presumably disruption of function of sodium channels is also the reason for the appearance of the repetitive CMAPs with oxaliplatin use, as well as causing the spontaneous high frequency motor unit activity seen on EMG.
Loss or disruption of CPC functions results in aneuploidy, chromosome imbalances, and ultimately cancer development.
Loss of empathy resembles the Augustinian concept of evil in that it is a deficiency of goodness – or, to put it less moralistically, a disruption of normal functioning – rather than a positive force.
via the disruption of HSP90 functioning (Bolden et al, 2006).
