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Therefore, the non-nuclear-localization may arise from disruption of functionality of HLH-30b/c::GFP fusion proteins and, as the cellular distribution is indistinguishable, this expression does not provide support for transcripts d/e.
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It said the attack caused "worldwide disruption of the functionality" of the internet.
Permanent plastic deformation of steel rebars is among the main reasons for the disruption of the functionality of RC structures after major seismic events.
A disruption of membrane functionality from an interaction between released Ag+ ions and the cell membrane and extensive cell membrane damage caused by the formation of ROS ultimately causes damage to the cell due to oxidative stress.
A disruption of membrane functionality from an interaction between released Ag nanoparticles/Ag+ ions and the cell membrane and extensive cell membrane damage caused by the formation of ROS ultimately caused damage to the cell due to oxidative stress.
More-performative actions, such as virtual sit-ins and e-mail bombs, provoke a concrete disruption of the servers' functionality through the concerted action of participants around the world.
The CYP1B1 mutations can be missense, nonsense, insertions, and deletions and result in the disruption of enzymatic activity and functionality of CYP1B1 protein [ 25, 31].
NetPhos uses sequence and structure-based neural networks for predicting phosphorylation sites at serine, threonine or tyrosine residues in protein sequences based on the premise that creation of new phosphoylation sites or disruption of existing ones can alter the functionality of a protein.
However, for individual branches it is in principle still possible that the loss of constraint occurred very recently, and that while missense mutations led to a change or loss of functionality as demonstrated in other GPCR [35], ORF disruptions have by chance not yet occurred.
From this understanding of autophagy as a dynamic integrator of numerous signalling pathways, it is evident that disruptions in the functionality of other pathways are likely to disrupt autophagy and therefore cellular homeostasis.
Information concerning these possible failures can help to minimise the disruption to the functionality of the system by allowing quick rectification.
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CEO of Professional Science Editing for Scientists @ prosciediting.com