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Hedden, T. et al. Disruption of functional connectivity in clinically normal older adults harboring amyloid burden.
Brain insults cause rapid cell death, and a disruption of functional circuits, in the affected regions.
Disruption of functional connectivity between brain regions may represent an early functional consequence of b-amyloid pathology prior to clinical Alzheimer's disease.
These results indicate that disruption of functional connectivity and hypometabolism may represent early functional consequences of emerging molecular Alzheimer's disease pathology, evolving prior to clinical onset of dementia.
Thus, disruption of functional survivin along its dimer interface with a small molecule is hypothesized to inhibit the proliferation of cancer cells and sensitize them to therapeutic agents and radiation.
Results Comatose patients showed a significant disruption of functional connectivity of brain areas spontaneously synchronized with PCC, globally notwithstanding etiology.
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Functional subnetworks perturbed by CIGB-552 were identified by using drugDisruptNet (http://bioinformatics.cemm.oeaw.ac.at/index.php/downloads-left/87-disruption-of-functional-networks).
We aimed to investigate if non-demented older individuals with increased amyloid burden demonstrate disruptions of functional whole-brain connectivity in cortical hubs (brain regions typically highly connected to multiple other brain areas) and if these disruptions are associated with neuronal dysfunction as measured with fluorodeoxyglucose-positron emission tomography.
Because the long lifespan of tropical trees [31], hypotheses addressing disruptions of functional diversity driven by changes in tree composition can be properly tested in landscapes that were disturbed long enough ago to permit demographic shifts to have occurred, such as fragmented landscapes with longer histories of human occupation.
Some studies have shown the disruptions of functional brain network modularity in patients with childhood-onset schizophrenia [ 10], schizophrenia [ 11, 12], epilepsy [ 13, 14], and chronic back pain [ 15].
In conclusion, we found anatomically overlapping disruptions of functional whole-brain connectivity and hypometabolism in amyloid-positive patients with mild cognitive impairment in posterior brain regions (posterior cingulate/precuneus).
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