Sentence examples for disruption of function from inspiring English sources

Understanding molecular mechanisms of toxicity is facilitated by experimental manipulations, such as disruption of function by gene targeting, that are especially challenging in non-standard model species with limited genomic resources.

Disruption of function by germline mutations in RET have been associated with several diseases in humans including three related inherited cancers: multiple endocrine neoplasia type IIA (MEN2A), multiple endocrine neoplasia type IIB (MEN2B), and familial medullary thyroid carcinoma (FMTC).

Furthermore, disruption of function in the postcentral gyrus (BA3) by cooling resulted in an augmentation of activity and enlargements of receptive fields of neurons in the homologous S1 suggesting that a potential role of callosal fibers in S1 is to mediate inhibitory information across hemispheres [11].

Does this mean that a single point mutation can be disfavored for a minor disruption of function?

The biology of adolescence is distinctive and provides opportunities for unique actions of toxicants both in terms of disruption of function and disruption of maturation.

Second, that SL interactions, which are defined between two genes when disruption of function of either gene product is viable but disruption of function of both simultaneously results in death, could be screened in genetically amenable model organisms to identify those that may be relevant to the treatment of tumors (Hartwell et al. 1997).

Disruption of functioning is also common in cancer patients and is frequently associated with anxiety (i.e. intrusive and unpleasant thoughts regarding recurrence, disability or death can disrupt the ability to concentrate, decision-making, sleep patterns, etc).

These include cardiac lesions [ 3], liver histopathology [ 4], compromised immune function [ 5] and disruption of intestinal function [ 6- 9].

These results strongly indicate a causal connection between AHR function, TCDD treatment, and disruption of cardiomyocyte function.

Importantly, disruption of podocyte function that disrupts the slit diaphragm often leads to nephrotic syndrome and progressive deterioration in renal function [1], [2].

Potential effects of BPA on cognition and behavior may thus be attributable in part to disruption of thyroid function.