Sentence examples for disruption of expression of from inspiring English sources

In recent years, the Cre/loxP-system has become the system of choice for the generation of conditional so-called knockout mouse strains, i.e. the tissue-specific disruption of expression of a certain target gene [1], [2].

The Cre/loxP-system has become the system of choice for the generation of conditional so-called knockout mouse strains, i.e. the tissue-specific disruption of expression of a certain target gene.

The Notch receptors Notch1 and Notch2 which are both required for the establishment of asymmetry were expressed normally in all E7.5 embryos (n = 17 and 13, respectively) from Tbx6 heterozygous matings (Figure 3A D) indicating that there is likely no major disruption of expression of these receptors in mutant embryos.

The disruption of expression of miRNAs has been found in many human diseases including cancers, neurological disorders, and cardiovascular disorders [ 15].

Disruption of expression of individual OBPs results in altered behavioral responses to multiple, but not all, odorants, and affects males and females differently (Fig. 3).

For example, disruption of expression of OBP28a shows altered behavioral responses to 2-heptanone and l-carvone in males and to 2-ethylpyrazine and citral in both sexes.

Integration is characterised by retention of the viral oncogenes E6 and E7, and by disruption or loss of expression of the viral transcriptional repressor E2, leading to deregulated production of E6 and E7 [ 4].

A disruption of the normal sequence of expression of genes that make these organs is responsible for this (Thewissen et al. 2006).

Disruption of Errβ-dependent regulation of expression of Cckbr and/or Crhr2 may at least partially explain the abnormal meal patterns and stress behaviors (e.g. acoustic startle response, Crh expression or corticosterone levels) observed in Sox2- Cre: Errβ lox / lox, Sox2- Cre: Errβ+/ lox, and Nes- Cre: Errβ lox / lox mice [ 14].

Surveillance of recent B. pertussis isolates in several countries has identified prn deletions and gene disruptions, which lead to lack of expression of mature prn (10 – 10 ).

Sarbani G., Poindexter K. M., Sundar S. N., and Firestone G. L. (2010) Arecoline induced disruption of expression and localization of the tight junctional protein ZO-1 is dependent on the HER 2 expression in human endometrial Ishikawa cells.