Sentence examples for disruption of expression from inspiring English sources
In recent years, the Cre/loxP-system has become the system of choice for the generation of conditional so-called knockout mouse strains, i.e. the tissue-specific disruption of expression of a certain target gene [1], [2].
The Cre/loxP-system has become the system of choice for the generation of conditional so-called knockout mouse strains, i.e. the tissue-specific disruption of expression of a certain target gene.
Brain homogenates from SV2B −/− mice lacked detectable SV2B protein as detected by immunoblot (western) analysis (Figure 1C), indicating that full-length SV2B protein is absent and thus confirming disruption of expression.
The Notch receptors Notch1 and Notch2 which are both required for the establishment of asymmetry were expressed normally in all E7.5 embryos (n = 17 and 13, respectively) from Tbx6 heterozygous matings (Figure 3A D) indicating that there is likely no major disruption of expression of these receptors in mutant embryos.
The disruption of expression of miRNAs has been found in many human diseases including cancers, neurological disorders, and cardiovascular disorders [ 15].
The inclusion of Smchd1MommeD1/+ female embryos in this analysis demonstrated that haploinsufficiency for Smchd1 was not sufficient to cause detectable disruption of expression for the affected genes.
Conclusions: Disruption of AHR expression levels resulted in gene expression changes that perturbed cardiomyocyte differentiation.
Next, we wanted to show that disruption of Cx43 expression or function would reduce expression of these genes.
Indeed, we found that siRNA disruption of CREB expression abolished genistein-induced eNOS expression and NO production.
The genome instability observed in the absence of menin may be caused by the mis-expression of Hsp70 or disruption of the expression of other genes.
This study also revealed disruption of SOX10 expression by VPA, which is expressed during the neural crest and glial lineage development.
