Thus we've now tested for an effect on nocodazole on the establishment of polarity, the disruption of polarity once it is established, and the recovery of polarity following cytochalasin wash-out.
Strumpf et al. [38] demonstrated that Cdx2 disruption caused peri-implantation embryonic lethality due to lack of establishment of the TE.
Together these data suggest that the disruption of cell:cell contact promotes the establishment of the mesoderm lineage and that MEDII has an opposing activity that suppresses the formation of this lineage in culture.
It's disruption on an establishment level, not a tech level.
Though it does not prevent chromatin association or Smc3 acetylation, disruption of the hinge's north interface prevents establishment of stable sister chromatid cohesion.
The synaptic phenotype of ttx-7 mutants is unique: the disruption of all examined genes related to synapse formation or polarity establishment did not cause the ttx-7 -like defects (Table 1; Tanizawa et al. 2006).
Therefore, restricting growth within macrophages may play an essential role in the establishment of latent infections, while disruption of these growth-restricting mechanisms can result in hypervirulence.
Disruption of the junctions, and the barrier they establish, is a common feature of disease states and is associated with the establishment of infections, increased inflammation, and malabsorption [ 28].
This result suggested that disruption of germ cells migration results in defects in the establishment of the initial (neonatal) SSC niche, eventually leading to impairment of SSC function.
However, the disruption of the breast tissue microenvironment architecture occurring during cancer establishment and progression leads to an extended leak of secreted extracellular molecules into blood circulation, causing their higher serum concentrations.
The devastation of large areas of the world and the disruption of economic relations during World War II resulted in the establishment (before the UN was founded) of the United Nations Relief and Rehabilitation Administration (UNRRA) in 1943.
