Sentence examples for disruption of components from inspiring English sources

Both acute exposure and gradual adaptation to hyperosmolal conditions lead to the accumulation of DNA damage and cause this accumulation by disruption of components of the DNA damage response pathway [8], [9].

Disruption of components of the p53 signaling pathway is associated with a poor prognosis in gastrointestinal tumors [ 2- 6].

Disruption of components of the cytoskeleton by various means, including nocodazole, cytochalasin D and attenuation of Rock function by small molecule inhibitors led to YSL expansion.

We show that disruption of components of the cytoskeleton induces the formation of an expanded YSL, and identify Rock1 as the regulator of cytoskeletal dynamics that lead to YSL formation.

We tested the expectation that power-law networks are robust to random disruption of component nodes by comparing the effect of environmental and mutational stresses on hub and random gene disruptions in E. coli.

First, we examined the liver and kidneys of mice with genomic disruptions of components of the IFN response mechanism on the C57BL/6 background [ 9] deficiencies eliminated all high Irga6 expression patches from the kidney and all Irga6 patches with mononuclear cores from the liver.

The tempering moisture of the feedstock was the main factor affecting disruption of fiber components because it directly affected the shear stress rate [ 3].

Our method shows that more than 20 components are essential to the activation of the transcription factor NFκB, as single-node disruption of these components blocks all the signaling paths and ESMs to NFκB.

Since similar changes occur in cardiomyocytes of syne1 null mouse (lacking nesprin 1) [42], this indicates that disruption of different components of the LINC complex cause a common phenotype.

Disruption of various components of this pathway leads to delayed and small (dwarf) flies [6], [8], [12], [16].

The targeted disruption of structural components or down-stream signaling proteins of the pre-B cell-receptor complex results in the arrest of B cell development.