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Eyeblink conditioning (EBC) is a widely used translational probe of cerebellar function in both humans and non-human animals.
Moreover, behavioral evidence also points to disturbances in cerebellar function in people with BD, who exhibit deficits in eyeblink conditioning, a sensitive assay of cerebellar function [27].
The simplest explanation is that impairment of cerebellar function does not form part of the neurobiology of SLI.
DOI: http://dx.doi.org/10.7554/eLife.06085.014 Delay eyeblink conditioning is a more precise assay of cerebellar function than two phenotypes that are commonly assumed to measure cerebellar function, rotarod and gait.
Furthermore, in the Discussion (second paragraph) we explore the advantages of using eyeblink conditioning as a probe of cerebellar function.
We now use the Discussion section to show how the data fit into a framework of cerebellar function.
We have reorganized the paper to emphasize the results before putting them into the context of cerebellar function.
Such mixing of mossy fiber inputs was a critical aspect of the expansion recoding of cerebellar afference performed by granule cells in the influential Marr-Albus theory of cerebellar function (Marr, 1969; Blomfield and Marr, 1970; Albus, 1971).
The localization of cerebellar functions has been under debate for more than a century.
17 Furthermore, the current understanding of cerebellar functions covers not only motor but also cognitive processes.
Ataxias are a heterogeneous group of neurological disorders characterized by loss of coordination due to alteration of cerebellar functions.
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