Sentence examples for disruption of cell division from inspiring English sources

Deficiency of folic acid also causes disruption of cell division along the gastrointestinal tract, which results in persistent diarrhea, and impaired synthesis of white blood cells and platelets.

Because APC-mediated degradation of substrates is required for cell-cycle progression, we sought to determine if increasing MCPH1 levels would lead to disruption of cell division.

We tested whether injecting mRNAs encoding hMCPH1 or dMCPH1-B into developing Xenopus embryos at the 2 4 cell stage would lead to disruption of cell division.

On the basis of these results, we suggest that TSA administration disrupts HDACs/PP1/tubulin complex, leading PP1-bound tubulin acetylation and stabilization, which is involved in disruption of cell division and induction of cell apoptosis.

Some mechanisms are chromosomal damage; disruption of cell division; and reduction in host resistance to cancer-initiating viruses, such as the Epstein-Barr virus, which can provoke a breakdown in the immune surveillance [ 42].

The disruption of cell division by altering gene expression levels in response to mitotic instability has been strongly correlated with tumor development and progression; both in vitro and in vivo evidence have demonstrated that in the absence of other cell cycle and DNA repair defects, mitotic disruption can transform cells and predispose them toward cancer [ 50].

Disruption of the normal regulation of cell division and differentiation plays a vital role in tumorigenesis (Vogelstein and Kinzler, 2001).

By introducing mutations that prevent SEPT9 self - association at the N- and C- termini, it has been shown that septin filament disruption causes defects in the late stages of cell division before abscission, similar to these observed upon SEPT9 depletion [ 28].

Other work in the kidney showed that disruption of PCP leads to randomization of the orientation of cell division that in turn causes dilation of tubules and formation of cysts, a major cause of ciliary disease (51– 51).

Thus, the TJ disruption in premalignant neoplastic tissue can increase the proba-bility that it will develop into a complete carcinoma because of the continuous stimulation of cell division followed by disrupted natural barriers between growth factors and their receptors.

The outcome of EGFR targeting is characterised by the disruption of a number of cellular processes that mirror the physiological consequences of EGFR signal transduction at the level of cell division, apoptosis and angiogenesis (Castillo et al, 2004).