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Uniquely for the TB-active amides, disruption of cell wall homoeostasis is identified as one target.
The mechanism of ZXR-2 involved disruption of cell membranes, as observed by scanning electron microscopy.
PEG-modified silica nanoflakes didn't produce a disruption of cell membranes and lactate dehydrogenase (LDH) release.
"The idea is to induce a generalised seizure that in some way has a pervasive brain-wide disruption of cell function..
Current red-blood-cell cryopreservation methods utilize bulk volumes, causing cryo-injury of cells, which results in irreversible disruption of cell morphology, mechanics, and function.
Lee SX, Wong ET, Swanson KD (2013) Disruption of cell division within anaphase by tumor treating electric fields (TTFields) leads to immunogenic cell death.
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Rack1 also blocks HGF-induced endocytosis of E-cadherin, disruption of cell-cell contacts and cell scatter.
Komatsu, M., Carraway, C., Fregien, N. L. & Carraway, K. L. Reversible disruption of cell-matrix and cell-cell interactions by overexpression of sialomucin complex.
HGF stimulates epithelial cell motility, inducing disruption of cell-cell junctions and subsequent cell scattering [43].
During this process, disruption of cell-cell adhesion and loss of functional junctions is a major event.
Similarly P-cadherin but not E-cadherin depletion in MCF10A cells led to disruption of cell-cell contacts and increased migration speed (Fig. 8).
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