This can be reduced by grouping genes into predefined groups according to a biological hypothesis such as grouping those with similar biological roles or within the same pathway, on the assumption that disruption of any one gene within a pathway or group will disrupt the functioning of that cellular response.
It was a total architecture of monitoring – divided for legal and clerical convenience into discrete code-worded programs, but functionally operating as an integrated apparatus of surveillance whose true capabilities are more than the sum of its subsystems, and which may be flexible enough to simply route around the disruption of any individual data source.
The disruption of any one of these processes can contribute to the mortality of bacterial cells.
Disruption of any subunit of the CO-controlling condensin dominantly changes DSB distribution, and thereby COs, and extends meiotic chromosome axes.
Disruption of any gene within a kernel causes catastrophic phenotypic results, and therefore, kernel structure is highly conserved (Davidson and Erwin 2006).
The very people who spend their days plotting the disruption of any industry touched by technology are themselves displaced by hordes of technology-enabled angel investors.
In the last years of his life, he seemed to anticipate his death and recognize human finitude more strongly as an inevitable disruption of any comprehensive systematic account.
Indeed, we find that inhibition of correct cleavage and corresponding mis-cleavage also results from disruption of any combination of active site contacts including metal ion interactions and conserved pairing interactions with the 3′ RCCA sequence.
As the knee derives its stability from ligament structures rather than from its osteochondral surfaces, disruption of any of the supporting ligamentous structures will likely alter the overall motion characteristics of the knee.
Therefore, it is reasonable to speculate that tissues with more sites of allelic imbalance have a greater likelihood of having disruption of any of the numerous critical genes that cause a cancerous phenotype and thus may have diagnostic or prognostic significance.
The methods developed here should permit the rapid and efficient disruption of any bacterial gene, the computational analysis provides new insight into group II intron target site recognition, and the set of E. coli DExH/D-box protein and DNA helicase disruptants should be useful for analyzing the function of these proteins.
