Subcellular organization of macromolecules underlies vital cellular processes such as development, division and homeostasis, while disruption of this organization is often associated with disease.
Among more interesting groups of proteins were those categorised as involved in the 'lipid biosynthetic process' (14 genes, P = 0.003; Figures 3, 4C) since disruption of lipid metabolism is often associated with low level metal toxicity [ 39, 40] and these changes can be associated with those regulated by the insulin axis.
It is possible that quinpirole-treated rats exhibited behavioural inflexibility, which is often associated with disruption of frontostriatal dopamine (reviewed in [47]), although the flexibility of observing response output in other phases of the study suggests that such a simple account of response-insensitivity is inadequate.
An area where new treatments are desperately needed is malignant cerebral edema, which is often associated with NVU/BBB disruption.
Epilepsy is often associated with a global disruption in cognitive development, however, it is still largely unknown how epilepsy affects the overall organization of overlapping cognitive domains.
In addition, this lesion is often associated with ossicular fracture or disruption [13].
ST-7 is often associated with intestinal symptoms and has been known to induce epithelial barrier disruption [ 8, 22].
Conversely, the disruption of lung structure during the course of acute and chronic inflammatory diseases of the lung is often associated with an imbalance of protease-antiprotease activity.
Neuromyotonia is often associated with autoantibodies against potassium channels [ 7], and it has been postulated that disruption of K+ channels is a key element in the production of neuromyotonia.
Infrastructure resilience is often associated with the ability of the hard infrastructure or physical system to cope with severe disruptions; however, the institutions and enterprises that make up the soft infrastructure systems are also prone to crises.
