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The causative agent or agents of duct disruption in the developing roach observed in this study are, however, unknown.
These results demonstrate that CENP-F disruption in the developing heart leads to decreased myocyte proliferation, reduced trabeculation, and a smaller and thin-walled heart.
Effects of endocrine disruption in the developing foetus are likely to be subtle and not readily apparent at birth, a lesson learnt from the disastrous case of DES (diethylstilbestrol). DES, a synthetic estrogen prescribed to prevent miscarriage ultimately turned out to be a cause of vaginal dysplasia, cervical adenosis and malformations of uterus and cervix.
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* Trade surpluses have allowed emerging markets to build up $3.2 trillion in foreign exchange reserves ($2.1 trillion, excluding China), which provides a strong buffer against any credit market disruptions in the developed world.
Using an antibody that recognizes both full-length GLI2-1855) and cleaved isoforms (GLI2-78) of GLI2, we found significant disruptions in both the developing facial prominences and limbs (Fig. 4).
Disruption of neuronal morphogenesis in the developing nervous system by pyrethroids could result in detrimental effects on neurological function later in life.
Disruption of fiber tracts in the developing brain could result in cortical cholinergic and monoaminergic deafferentation and impact attention, emotion and goal-directed behavior [ 99].
This study also supports the view that unilateral disruption of diffuse networks in the developing brain can lead to impaired executive function skills.
Despite the overall disruption to epithelial organization in the developing kidneys, examination of cilia highlighted by immunofluorescence with acetylated tubulin revealed no obvious difference in cilia morphology between WT and Atmin Gpg6/Gpg6 (Fig. 3A and B).
Reduced anogenital distance, retention of nipples or areolas, hypospadias, agenesis of sex accessory tissues, and undescended testes have been described as consequences of disruption of androgen action in the developing rat.
Despite the overall disruption to epithelial organization in the developing tubules, immunolabelling with the apical membrane marker aPKCζ showed normal apical localization of this protein on the luminal side of tubules in both WT (Fig. 2G) and homozygous kidneys (Fig. 2H and I).
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