To answer this question, we analysed the distribution of initial frame disruptions in sequences relative to the placement of protein structure domains from the SCOP data (see Methods for details).
Susceptibility testing showed that both XM1570 and the J53 transformants were susceptible to amikacin as previously observed in A. lwoffii, which was suggested to be a result of disruption in the promoter sequence of aphA6 [ 20, 24].
We termed a TAAR a putative pseudogene if there was high sequence similarity to a known TAAR but there was no obvious open reading frame or if there was a disruption in the coding sequence that was predicted to produce a truncated or abnormal product.
The aetiology of Sprengel's deformity is related to limb bud formation, which results in disruption of normal sequence of development during the foetal period [1, 2].
We perform statistical calculations which demonstrate non-random distribution of the initial frame disruptions in these sequences with respect to: (i) protein domain annotations, (ii) alternative exons and (iii) rules for nonsense-mediated decay (NMD).
Use of electronic medical records was found to influence the way patient data were gathered, resulting in information loss and disruption of temporal sequence of events in assessing patient problem.
This defect was accentuated in scarred, hydrocephalic cases, which suggested the occurrence of a non-specific disruption in the orderly apoptotic sequence found in control mice.
The effects of independently mutating each of these elements were nonadditive; disruption of either sequence resulted in complete or severe reductions in TGF-beta responsiveness.
Under conditions of auditory deprivation, neural reorganization is hypothesized to result in disruption of cognitive sequencing abilities.
In plants, the GT splice donor site is present in almost all introns [19] and disruption of the sequence often leads to mis-splicing [20].
The viral strain now in Brazil, he says, is "clearly new, different, and vastly more dangerous," with what appears to be a "truly causal" relationship to microcephaly — in Brazil, Attaran writes, the effects of microcephaly have been "suggestive of 'fetal brain disruption sequence' in which the developing brain and skull collapse while other anatomical features like the scalp skin keep growing".
