Bulk basipetal polar auxin transport has been demonstrated in moss sporophytes, and application of polar auxin transport inhibitors (PATIs) causes severe disruptions in development, resulting in the formation of multiple sporangia [ 32, 33].
Thus, in addition to the embryonic beltless phenotype, we observed that blt silencing produces a major disruption in egg development and maturation in adult females.
Axotomy provokes a serious sensorimotor disruption, early in development, and coordination of the limbs during walking does not entirely rely on the reinforcement of individual muscles.
Embryos injected with control MO exhibited normal forebrain development, whereas fezf2 MO caused significant disruption in the development of the forebrain, as revealed by diminution in the expression of the rostral forebrain-specific marker arx (Fig. 1A) as well as the anterior neural markers otx2 and pax6 at stage 30 (supplementary material Fig. S4A) (El-Hodiri et al., 2003).
This combination of incomplete penetrance and pleiotropic phenotypes could indicate that these loci cause a global disruption in brain development, making it more vulnerable to develop a range of different brain disorders.
For investigators to understand the role of endocrine disruption in brain development, it was necessary to first understand how thyroid hormones regulate brain development.
If there is a disruption in the development for example, through serious trauma that is not addressed early on, it could result in life-long development problems.
Epilepsy is often associated with a global disruption in cognitive development, however, it is still largely unknown how epilepsy affects the overall organization of overlapping cognitive domains.
And while they don't specifically mention Google, it seems pretty clear who they're thinking about when they write that a termination of existing licensing agreements "would result in considerable disruption in the development and enhancement of various existing technologies and give the prospective purchaser an unfair competitive advantage".
The unique positioning of the liver at the juncture of the peripheral circulation and the portal circulation augments the interaction between naïve T cells and other hepatic cells and leads to the disruption in the development of tolerance to commensal bacteria and other environmental agents.
