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p300/CBP disruption has proved a promising therapeutic option for several animal models of different types of thrombocytopenia.
While gene disruption has proved impossible, studies using transgenic complementation approaches and inhibition of endogenous PfAMA1 using the R1 peptide have been successful (Healer et al., 2004; Drew et al., 2012).
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At the same time, colleges and universities must take no comfort in the fact that prior predictions of technological disruption have proven false.
The former phase has granted fair access to storage, narrowed the likelihood of strategic behaviour by the incumbent and secured residential users against supply disruptions, but it has proved dynamically inefficient.
Hollywood has proved so resistant to disruption because relationships with talent, a feel for disparate audience segments, and a knack for providing global satisfaction aren't things that a startup can easily replicate.
For example, while cloud computing has proved to be a significant disruption to enterprise computing, many companies are not comfortable with the security of the cloud.
Citing national security has proved less persuasive than it once was when it comes to sonic disruptions caused by jets and other military activity.
The taxi app company has proved to be one of the most aggressive of the new generation of tech startups – showing a willingness to take "disruption" to new heights.
That has proved inadequate.
He has proved that.
This has proved hard.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com