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The publication of the B. subtilis genome sequence [ 17] and subsequent international programmes of systematic gene disruption, functional analysis and regulatory network studies [ 18], makes this microorganism a prime candidate to develop systems biology.
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These results indicate that disruption of functional connectivity and hypometabolism may represent early functional consequences of emerging molecular Alzheimer's disease pathology, evolving prior to clinical onset of dementia.
Disruption of functional connectivity between brain regions may represent an early functional consequence of β-amyloid pathology prior to clinical Alzheimer's disease.
The interrelation between hypometabolism and disruption of functional connectivity may reflect a link between synaptic failure and functional disconnection.
Brain insults cause rapid cell death, and a disruption of functional circuits, in the affected regions.
Results Comatose patients showed a significant disruption of functional connectivity of brain areas spontaneously synchronized with PCC, globally notwithstanding etiology.
Disruption in functional connectivity is due to direct tissue loss and indirect disconnections of remote areas known as diaschisis.
Thus, disruption of functional survivin along its dimer interface with a small molecule is hypothesized to inhibit the proliferation of cancer cells and sensitize them to therapeutic agents and radiation.
Additionally, in a growing resting state fMRI studies the disruption of functional connectivity networks in epilepsy have been reported [32], [33].
Therefore, genetic disruption or functional polymorphisms in both SOD1 and SOD2 can lead to defective spermatogenesis.
Other studies using fMRI demonstrated disruption in functional network connectivity with alcohol administration during tasks.
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