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We compute the experimental Structure Disruption Coefficient (eSDC) to evaluate the effect of a SNP on the RNA structure as described in the Methods (Equation 1).
eSDC: experimental Structure Disruption Coefficientl; pSDC: predicted Structure Disruption Coefficient; SHAPE: Selective 2'-Hydroxyl Acylation analyzed by Primer Extension; SNP: Single Nucleotide Polymorphism; FPR: False Positive Rate; TPR: True Positive Rate SNRNASMM: Single Nucleotide Resolution Nucleic Acid Structure Mapping.
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Figure 4 illustrates the four metrics applied to the ensemble of structures from each algorithm and used to generate pSDC values (predicted Structure Disruption Coefficients, Equation 4, methods).
The impact of such erroneous associations on the interpretation of the data as outlined in this paper will be limited by the approach of characterizing alterations at the level of metabolic pathways, involving multiple metabolites (the approach taken in this study), rather than considering the disruption of single correlation coefficient between two metabolites.
Similarly, selectivity seems to be the explanation for the association between civil marriage and marital disruption as well, even though the coefficient of the effect of civil marriage on the hazard of disruption does not decrease in the simultaneous model.
Then, two-way hierarchical clustering was performed to plot the heat map describing the correlation coefficient of pathway co-disruption.
This allows more advanced metrics than just the average diffusion coefficient to be calculated and disruption of white matter tracts to be visualised.
Interestingly, the diffusion coefficient of Eag1 was not affected by disruption of F-actin.
If the development of the current disruption begins at the center of the plasma sheet, this coefficient will be less than that at the beginning of the EO and equal to the estimated value only at the end of the current disruption.
This disruption is manifest in the significant decrease of the scaling coefficient characterizing long-range correlations, or "whitening" of the noise while the mouse misbehaves.
To quantitatively evaluate the topographical overlap between the patterns of whole-brain connectivity disruption and hypometabolism in mild cognitive impairment, we calculated a dice coefficient of similarity between the two findings (Zou et al., 2004).
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