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Exact(38)
The highest disruption capability was achieved at CDR 78.96% of the amount of cells disrupted in run 20 and the lowest capability of cell disruption was observed in run 3 with CDR of 27.64%.
Subsequent passes would treat more resistant cells, resulting in lower cell disruption capability [ 35].
Additionally, a non-linear correlation between cell disruption capability and the specific protein release was observed for cell disruption process.
Thus, it was concluded that measurement on cell disruption capability alone would not sufficiency evaluate disruption efficiency.
The F-value for both cell disruption capability (11.53) and specific protein release (74.01) indicates that the model is significant.
The results also demonstrated that cell disruption capability shares close relationship with the release of specific protein to a certain extent (Table 1).
Similar(22)
Although both the soluble and immobilized peptides demonstrated membrane disruption capabilities, the latter showed a slower rate of kill, presumably due to reduced diffusivity and flexibility resulting from conjugation to the polymer brush.
For example, when high cell disruption capabilities were observed in experimental runs 15 20 (CDR >70%), high concentration of HBsAg (> 28 mg/L) were obtained.
However, although high cell disruption capabilities was observed in experimental runs 5 10, lower levels of HBsAg concentration were detected (8.65-15.10 mg/L).
Minor: Medium financial loss, minor disruption to capability, minor impact on community standing.
Serious: High financial loss, some ongoing disruption to capability, modest impact on community standing.
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