Sentence examples for disrupting their function from inspiring English sources

Once such regions have been identified, the next step is to investigate their phenotypic impacts, for example by experimentally disrupting their function and observing the consequences (Vollbrecht and Sigmon 2005; Doebley et al. 2006).

As well as affecting transcriptional regulation, repeat sequences can alter the sequences of genes without disrupting their function.

RNA foci are thought to cause cellular toxicity by sequestering specific RNA-binding proteins in a sequence-dependent manner, consequently disrupting their function [ 4].

Evidence is emerging that cell cycle regulators play an important role in the division of Drosophila neuroblasts, and disrupting their function may give rise to tumorigenesis.

Chorion components of the fruit fly eggshell, for example, provide the embryo with protection from the physical environment, and disrupting their function causes female sterility [ 27].

Although almost all human FA homologs are found in most multicellular animals, and several are present in yeast, the final outcomes of disrupting their function in these systems does not precisely recapitulate the human outcome.

Overall, these experiments strongly suggest that overproduced Ndc80 absorbs its binding partners (e.g. Dis1), thereby disrupting their functions (Fig. 4D).

Here we show that Pa-cad and Pa-Wnt1 are expressed in the posterior GZ and disrupting their functions using RNAi or chemical inhibitors produce embryos with segmentation defects and revealed two distinct phases of Pa-cad and Pa-Wnt1 function.

Given their importance in the biology of many organisms, the concept that ticks might utilize serpins to evade host defenses and immunizing against or disrupting their functions as targets for tick control is an appealing option.

In Ukraine and Kyrgyzstan high turnaround of individuals' membership in national and subnational councils, reflecting a volatile political context, was reported as disrupting their functioning [ 28, 29, 34, 35].

He has shown that the APOE e4 gene produces a misshapen protein that can glom on to energy producing structures inside neurons called mitochondria and disrupt their function.