Sentence examples for disrupting the binding from inspiring English sources

The strategy of peptide stapling was used to develop new molecules to inhibit the hepatitis C virus infection via disrupting the binding of HCV envelope glycoprotein E2 with human cell surface protein CD81.

Disrupting the binding interaction between proprotein convertase (PCSK9) and the epidermal growth factor-like domain A (EGF-A domain) in the low-density lipoprotein receptor (LDL-R) is a promising strategy to promote LDL-R recycling and thereby lower circulating cholesterol levels.

Subsequent biological screening resulted in the first identification of a compound with confirmed Ku-inhibitory activity in the low micro-molar range, capable of disrupting the binding of Ku70/80 to DNA substrates and impairing Ku-dependent activation of another NHEJ factor, the DNA-PKCS kinase.

Thus, combinations of substitutions acting as epitope determinates in the EDII fusion peptide have a greater effect than do individual substitutions on disrupting the binding of some antibodies in this region.

A mutation in AKAP9 has also been shown to cause long QT syndrome subtype 11 by disrupting the binding to KCNQ1 leading to reduced cAMP-stimulated PKA phosphorylation of the KCNQ1-channel and a prolonged repolarization period [30].

Our study indicated that Hsp70 interacted with PB1 and PB2 of RNP and could interfere with the integrity of RNP and block the virus replication in vitro and in vivo possibly through disrupting the binding of viral polymerase with viral RNA.

Even though the N-terminal domain of L11 is connected with the mobile L10, it does not bind with the aa-tRNA, and therefore the movement does not disrupt the binding between the aa-tRNA and the GAC.

These pseudoknot fluctuations disrupt the binding site by facilitating fluctuations in the 5′-end of helix P1.

In conclusion, this is the first report of small peptides designed to disrupt the binding of SARS-CoV S protein to ACE2.

Thus, our work demonstrates for the first time how a regulatory SNP disrupts the binding of a master transcription factor NFκB and a key signaling pathway FAS in immune regulation and programmed cell death modifying Cystic Fibrosis.

Compounds that disrupt the binding of the excision reaction substrate(s) (the blocked primer and/or ATP and/or pyrophosphate), or mimic the dinucleoside tetraphosphate product of the ATP-based excision reaction are potential inhibitors of excision.