Hypofunction of the salivary glands can cause various life-disrupting side effects, such as dental caries, swallowing difficulties, loss of taste, and oral candidiasis.
On the contrary, the breadth of miR-mediated effects also brings potential for disrupting cellular function through unwanted side effects [ 89].
The monarch may also be the first sign that food webs in the U.S. Midwest are being irrevocably disrupted as a side effect of widespread planting of herbicide-tolerant crops, Brower says.
Erbitux's rejection thrust Iressa into first place in the race to bring to market a new class of cancer drugs that disrupt cellular growth without the wretched side effects of chemotherapy.
Flo Leighton, a psychiatric nurse practitioner in New York City, says post-traumatic stress disorder and bipolar disorder are two examples of psychiatric illnesses that have side effects that disrupt normal sleep patterns.
John McLaren, an economist at the University of Virginia who has researched the effects of Nafta, cautioned that changing the rules now could have unintended side effects if they disrupt the supply chains that industries have built up around the existing Nafta rules.
However, the Rock-Myosin II pathway is central to numerous cellular processes and signaling networks (Wei et al., 2001; Thumkeo et al., 2003; Shimizu et al., 2005; Thumkeo et al., 2005; Kamijo et al., 2011), suggesting that global inhibition of Rock function would likely disrupt multiple cellular processes with detrimental side effects.
Thus, HSP47 inhibition with siRNA or some other inhibitors might be a good choice for the treatment of fibrotic disorders without disrupting the cellular homeostasis and with fewer side effects.
Figuring out exactly what rate to use is tricky, though while it has to be high enough to control symptoms, if it's too high patients can suffer side effects including unwanted movements, disrupted speech or cognitive problems, says Grill.
CLR01 binding to lysine residues could potentially disrupt normal protein function leading to toxicity or side effects.
The trial will also be disrupted if there are serious, not yet known, side effects to the drugs used.
