According to this perspective, disrupted prediction error signalling is thought to underpin many of the signs and symptoms of schizophrenia.
Moreover, such disruption is thought to be of central importance to the genesis of psychotic illness (Corlett, Murray et al., 2007), and as such, studies linking schizotypy to disrupted prediction error signalling may be especially informative (see, for example, Corlett et al., 2009).
Furthermore, given the hypothesised role of disrupted prediction error signalling in the genesis of schizophrenia, our observation that SoA has an associative basis, and which in turn may be linked to dopamine function, is also relevant to understanding impaired SoA associated with that disorder (see Section 4.2).
As discussed, dopamine agonists can have deleterious effects on decision making in the face of uncertainty and reward in Parkinson's disease by disrupting reward prediction error, or learning from losing (van Eimeren et al., 2009).
3) The tested binding sites harbored nodal variants, which did not disrupt the prediction score of the TF-binding motif.
To assess the accuracy of predicted structure disrupting mutations, we compared our predictions to experimental data obtained on the purine riboswitch using 2D SHAPE (Selective 2'-hydroxyl acylation analyzed by primer extension) [ 52].
As Kimport et al. (2012) note, such findings disrupt anti-abortion predictions about the impact of ultrasound on women seeking abortions.
A laboratory experiment finds that subjects tasked with disrupting a dark network qualitatively mimic the theoretical predictions.
That is, disrupting function in the right cerebellum selectively impaired the prediction aspect of sentence processing in this task; other language processes were spared.
Although these mutations have been predicted to disrupt Myo1e activity, testing this prediction directly in a vertebrate model organism is challenging, not only owing to the need for complex genetic modifications but also because of the limitations of microscopic and biochemical characterization in such a model.
Among different types of regulatory elements, the prediction methods work best in identifying pathogenic ncSNVs disrupting a promoter (Fig. 2d).
