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As opposed to disrupting memory for the original event, as proposed by Chan and LaPaglia (2013), the results of the present study indicate that interim testing may benefit memory for the original event, and tentatively suggest that interim testing may improve discrimination between original and post-event details.
Bearing these two facts in mind, we asked whether sulfasalazine during the reconsolidation protocol could induce memory extinction by prolonged NF-κB inhibition during memory reactivation rather than by disrupting memory reconsolidation.
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Using a drug typically given to organ-transplant patients, researchers at the University of California, San Francisco, reduced the incidence of relapse in rats by disrupting memories linked to past drinking.
In the mainstream media, it's commonly referred to as the "date rape drug," due to its effects of putting users into a deep unconscious state and disrupting memories.
A recent rTMS (repetitive transcranial magnetic stimulation) finding also indicated the importance of left DLPFC activity for self-initiated elaborative encoding by demonstrating that the disruption of left DLPFC activity disrupted memory performance only in the self-initiated encoding condition but not in the instruction-provided condition [ 49].
Exposure to acute stress for 30 min immediately before the test phase of either test disrupted memory retrieval.
More complex interruptions, such as secondary search tasks, have been shown to disrupt memory for visual search arrays after only a few seconds, and this memory seems to be completely eradicated by interruptions with longer durations (Shen & Jiang, 2006).
To figure out whether the disrupted memory formation of silver mutant resulted from the abnormal development or the interference of physiological process of neural system, we acutely manipulated the expression of svr + transgene in adult flies with the TARGET system.
Similarly, environmental manipulations that disrupt circadian rhythms without genetic mutations also disrupt memory in different tasks [27] [30].
Earlier work with rats also found that both advances and delays of the LD cycle disrupted memory [34].
Similarly, environmental manipulations, including chronic phase shifts of the LD cycle, that disrupt circadian rhythms without genetic mutations also disrupt memory in different tasks [28] [34], [69], [77].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com