Finally, how you're disrupting matters.
Whereas many of these disabilities have been attributed mostly to white matter injury, disrupted grey matter development also appears to contribute to disabilities of preterm survivors [ 2].
Traumatic brain injury appears to modulate this existing relationship by disrupting white matter structure, thereby shifting patients along an existing continuum into a less efficient structure-function relationship.
Furthermore, aging is associated with disrupted white matter anatomical connections, specifically in the frontal white matter, anterior cingulum, and the genu of the corpus callosum (Salat et al., 2005; Madden et al., 2012).
Given the accumulating evidence that disrupted white matter integrity may be central to the pathophysiology of bipolar disorder, white matter abnormalities represent a promising candidate for a neuroanatomic predictor of outcome.
Polymicrogyria (PMG) is a cortical malformation characterized by multiple small gyri and altered cortical lamination, which may be associated with disrupted white matter connectivity.
X-ray observations indicate that the Galactic black hole Sgr A∗ is inactive now, however, we suggest that Sgr A∗ can become active when a captured star is tidally disrupted and matter is accreted into the black hole.
That finding is consistent with disrupted white matter anatomical connections between occipital and temporal areas in the elderly (Kantarci et al., 2011).
Some evidence supporting this comes from a case study of a single patient who had a lesion in left posterior middle temporal gyrus, no damage at all to the left inferior frontal gyrus and disrupted white matter tract connections between left posterior middle temporal gyrus and left inferior frontal gyrus (Tyler and Marslen-Wilson, 2008).
The environment — crowds, noise, disrupted routines — matters, too.
