Sentence examples for disrupting interaction from inspiring English sources

The main goal of this study was to identify small molecules that by disrupting interaction between two receptors and inverting the ratio between active ERK and p38 will force disseminated cancer cells into a state of dormancy.

This active sequence binds to the BIR domain of IAPs, disrupting interaction with both pro- and active caspases, thus promoting their activation and function.

Phosphorylation of CRY1 by AMP-activated protein kinase (AMPK) increases its association with FBXL3 (Lamia et al., 2009) by disrupting interaction with PER (Xing et al., 2013).

Strikingly, we found that five of the six most common pathogenic mutations (R1441C, R1441G, R1441H, Y1699C and I2020T) display markedly reduced phosphorylation of Ser/Ser thereby disrupting interaction with 14-3-3 14-3-3 14-3-3

Small-molecule inhibitors disrupting interaction of viral proteins with the CRL machinery or blocking the activity of the hijacked E3 ligase complex could lead to the development of novel antiviral therapies.

Tested singly in a yeast two-hybrid test, each mutation perturbed the interaction of Vac14p with Vac7p and Atg18p, without disrupting interaction with its other binding partners (not shown).

Risk alleles at disease-associated SNPs favor decreased PRE occupancy, thereby disrupting interactions between PREs and trans-acting factors (e.g., AP-1).

On the other hand, the p.R407C mutation is compatible with secretion, but rather may exert its pathogenic effect by disrupting interactions with ADAM proteins.

The ΔF508 mutation inhibits folding by disrupting interactions between NBD1 1 and intracellular loop 4 (inL4) in the second transmembrane domain (TMD2) (5).

But if the proposed cation-π interaction is important for AdA binding, mutation of R504 might additionally reduce AdA binding by disrupting interactions with its adenine ring.

It functions as a sialidase to cleave off the terminal sialic acid (SA) on the budding virus, disrupting interactions between SA receptor and virus hemagglutinin 24, 25.