Sentence examples for disrupting expression from inspiring English sources

We developed a variation on this approach that allows the random insertion of gfp into target genes in their normal chromosomal context, without disrupting expression of upstream or downstream genes.

This phenotype is characteristic of Abd-B m mutations [27], [28], suggesting that the P element insertion into the PTE is disrupting expression from the adjacent Abd-B m promoter and is consistent with a reduction in IAB5-7 enhancer-Abd-B interactions.

This does not eliminate the possibility that the RNAi is also disrupting expression of other genes.

The functions of TbARL6 were investigated by disrupting expression in T. brucei BSF parasites using tetracycline-inducible RNA interference (RNAi).

These analyses suggest that, rather than completely disrupting expression of Serinc1, this mutation modulates expression and represents a hypomorphic allele.

Due to the position of the transposon insertion, we postulated that, rather than completely disrupting expression of Serinc1, the mutation may affect gene regulation.

Therefore the disrupted expression of IGFBP7 by aberrantly expressed miRNAs during the gonocyte to spermatogonia transition could have implications for their growth and differentiation.

We can observe that the closest neighborhood of a significant candidate is highly differentially expressed and belongs to a more disrupted expression module than the neighborhood of a nonsignificant candidate.

Further, JA-deficient mutants, with a disrupted expression of OsAOC also show typical developmental phenotypes such as early flowering, elongated sterile lemma, and reduced fertility (Riemann et al. 2013).

Here we report that mice with heterozygous loss of Chd7 function exhibit delayed semicircular canal genesis, delayed Netrin1 expression and disrupted expression of genes that are critical for semicircular canal formation (Bmp2, Bmp4, Msx1 and Fgf10).

As a result, the insertion does not disrupt expression of the gene.