Moreover, simultaneous knockdown of MAF1 with either Pol III or BRF1 (a subunit of TFIIIB) disrupted the looping formation.
The authors state that 'Moreover, simultaneous knockdown of MAF1 with either Pol III or BRF1 (subunit of TFIIIB) disrupted the looping formation.
The Lin28 rs3811463 (T/C) SNP, located near the let-7 binding site, might disrupt the loop of Lin28/let-7.
TP53 mutations disrupting the loop 2 and loop 3 domains of the protein have been shown to predict poor survival in breast cancer (Borresen et al, 1995) and colorectal cancer (Borresen-Dale et al, 1998).
In a recent investigation of TBCE function in Drosophila, RNAi knockdown of either presynaptic or postsynaptic TBCE disrupted the distinctive microtubule loop structures present at the fly neuromuscular junction [54].
Background/Purpose: Recently, the authors have shown that in human fetuses suffering from gastroschisis, there is an amniotic fluid inflammatory response and that amniotic fluid exchange designed to disrupt the inflammatory loop seems to have a favorable impact on outcome.
Perhaps we're overlooking a critical goal and in doing so have not properly internalized a critical reward, disrupting the feedback loop necessary to prompt lasting habitual change.
Almost human-like, a pair of strung spherical orbs one black and electromagnetic, one white and not circle haphazardly around the polar base, randomly jumping and disrupting the hypnotic loop at the sudden burst of magnetic force, to Musical's Cage-ian "naked sound".
ADT involves administering luteinizing-hormone-releasing hormone agonists or antagonists to disrupt the feedback loop within the hypothalamic gonadal axis, suppressing testosterone production by the testes.
However, unlike treatments that disrupt the telomere loop, T-oligos do not cause digestion of the 3' telomere overhang (repeats of TTAGGG sequences) or otherwise alter endogenous chromosomes [ 10].
