Sentence examples for disrupted signaling from inspiring English sources

In previous research, he and his colleagues disrupted signaling in the fish's habenula and showed that this made them more likely to act "helpless" at the prospect of an electric shock.

We performed both GSEA aimed at identifying disrupted signaling pathways as well as analyses to identify individual, differentially expressed genes between spt and wild-type tissue.

Moderate acidosis at pH 6.8 potently disrupted signaling by receptors for prolactin but not epidermal growth factor, oncostatin M, IGF1, FGF or growth hormone.

Following the depletion of palmitate, gene expression in tumor cells is altered on a global scale, lipid raft architecture is disrupted, signaling pathways are inhibited and ultimately the tumor cell dies through an apoptotic mechanism.

Disrupted signaling events include the RIG-I/MDA5 cascade and type I interferon (IFN) response as well as induction and suppression of anti-inflammatory (IL-10) and proinflammatory (IL-12 and TNF- α) cytokines, respectively [ 73].

In summary, we have identified six genes acting downstream of tbx16 in the posterior mesoderm at the 21-somite stage, only one of which (aldh1a2) is embedded within a more globally disrupted signaling pathway (retinoic acid signaling).

The ongoing cancer research has shown that malignant tumour cells have highly disrupted signalling transduction pathways.

Thus, extra centrioles and cilia disrupt signaling and may contribute to disease phenotypes.

In all these social organisms, external factors can disrupt signaling mechanisms and induce expanding self-perpetuating rogue behavior, leading to social disintegration.

However, recent discoveries regarding the regulatory mechanisms that control p110β activity suggest alternative strategies by which to disrupt signaling by this PI 3-kinase isoform.

Infectious agents have evolved strategies that disrupt signaling pathways normally leading to a protective cellular reaction.