Sentence examples for disrupted pathway from inspiring English sources

The reaction provides an alternate route to the formation of dihydroxyacetone, thereby allowing a metabolic bypass of the disrupted pathway.

We define a disrupted pathway as one whose members (genes) are directly altered, or they interact (based on the protein-protein interaction network) with many altered genes.

When looking into the characteristics of the tested compounds/drugs genes/protein interactions, Mg2+ and rapamycin are highlighted as the most efficient drugs in silico to target this disrupted pathway, which is here represented in silico by NOWADA network (Supplementary Table S10).

68 An evaluation of 98 models or tumor samples of osteosarcoma showed very few point mutations of oncogenes and tumor suppressor genes commonly mutated in carcinomas; the PI3K pathway did emerge as a recurrently disrupted pathway in a subset of the patients.

Increased expression of MMSET is also reported to contribute to the constitutive activation of nuclear factor-κB, a commonly disrupted pathway in MM, and inhibition of MMSET in vitro reduces cell growth of the malignant cells, providing a potential therapeutic target.

Our claim is that, in CF, among the multitude of (disrupted) pathway possibilities [ 40– 42], a single protein kinase, CK2, stands apart as being the most pleiotropic of all, exerting simultaneous control of many hundreds of substrates across fundamental CF-related cellular processes, while always appearing to be active 'in cell' and yet manifesting lethality when deleted.

Combining these two disrupted pathways, a sextuple mutant (Δfaa1 Δfaa4 Δfat1 Δfaa2 Δpxa1 Δpox1) was able to produce 1.3 g/L extracellular free fatty acids.

Studies of these rare variants using hiPSCs have the potential to identify commonly disrupted pathways in schizophrenia and allow for the identification of new therapeutic targets.

Saporin lesion of MS, DBN (horizontal limb), or MS + DBN had no anticonvulsant effects, suggesting that aspiration lesion of MS disrupted pathways beyond cholinergic ones.

It has become widely acknowledged that disrupted pathways, as opposed to deregulated individual gene, drive the tumorigenesis process [58].

This observation demonstrates the role of disrupted pathways associated to BRCA1 down-regulation in the centrosomal instability of CML cells.