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It is important to note that apoptosis of structural cells such as endothelium or epithelium in systemic inflammatory response syndrome is associated with disrupted organ function [ 5, 6].
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Left unchecked, they can spread throughout the body and disrupt organ function.
The fibrils directly disrupt organ function; however, other pre-amyloid misfolded forms of the protein are also implicated in disease pathophysiology (Gavrin et al., 2012).
For example, when inhaled, nanomaterials less than 100 nm can induce pulmonary inflammation and oxidative stress (56) and disrupt distal organ functions through mechanisms including hydrophobic interactions, redox cycling, and free radical formation.
Myofibroblasts are effector cells in SSc fibrosis, which either produce excessive fibrillar collagens in the accumulated ECMs or disrupt the normal tissue architecture, leading to the loss of organ function [1,2,9].
Sequential organ function assessment.
Physiological indices of organ function were recorded.
Thus, blocking iNOS may improve organ function.
Aging impairs organ function.
TsES did not impair organ function).
The studies required adequate visceral organ function.
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