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A recent rTMS (repetitive transcranial magnetic stimulation) finding also indicated the importance of left DLPFC activity for self-initiated elaborative encoding by demonstrating that the disruption of left DLPFC activity disrupted memory performance only in the self-initiated encoding condition but not in the instruction-provided condition [ 49].
Exposure to acute stress for 30 min immediately before the test phase of either test disrupted memory retrieval.
To figure out whether the disrupted memory formation of silver mutant resulted from the abnormal development or the interference of physiological process of neural system, we acutely manipulated the expression of svr + transgene in adult flies with the TARGET system.
Earlier work with rats also found that both advances and delays of the LD cycle disrupted memory [34].
A recent study showed that peptide inhibition of PKMξ (Protein Kinase M) in the insular cortex one month after training disrupted memory for conditioned taste aversion (CTA)[10].
In our experiments, ZIP disrupted memory after the animals had reached asymptotic performance following several weeks of training, but it cannot be excluded that at some point in the future the memory would become independent of the kinase.
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Inhibition of ephrinA/EphA receptor signaling by soluble EphA5 extracellular domain fragments demonstrated a role of EphA receptor signaling in synaptogenesis and hippocampal connectivity, most likely acting at the postsynaptic side [41], and disrupted memory-based behavioral tasks [42].
More complex interruptions, such as secondary search tasks, have been shown to disrupt memory for visual search arrays after only a few seconds, and this memory seems to be completely eradicated by interruptions with longer durations (Shen & Jiang, 2006).
As opposed to disrupting memory for the original event, as proposed by Chan and LaPaglia (2013), the results of the present study indicate that interim testing may benefit memory for the original event, and tentatively suggest that interim testing may improve discrimination between original and post-event details.
Similarly, environmental manipulations that disrupt circadian rhythms without genetic mutations also disrupt memory in different tasks [27] [30].
Similarly, environmental manipulations, including chronic phase shifts of the LD cycle, that disrupt circadian rhythms without genetic mutations also disrupt memory in different tasks [28] [34], [69], [77].
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