Sentence examples for disrupted linkage from inspiring English sources
In the case of CLOCK and ADCYAP1, however, several pieces of evidence point against disrupted linkage as the source of variation in the genotype-phenotype relationship.
Given the existence of a known mechanism that could relate allelic variation in CLOCK and ADCYAP1 to functional consequences (detailed above), disrupted linkage seems less likely to account for variable strength of association than other possible causes.
A third possibility is that recombination in subsequent generations has disrupted linkage disequilibrium between linked QTL so that the QTL effect at the position tested in the current study deviates significantly from the one observed in the F2 generation.
In contrast, unobstructed gene flow between chromosomes with similar arrangement would disrupt linkage associations within each species and create new genetic variation for selection to act upon.
Finally, we compared the extent of homozygosity of these haplotypes with others of similar frequency, in order to verify that the haplotypes had risen rapidly to high frequency before recombination events had time to disrupt linkage disequilibrium.
In Russia, the Soviet legacy still renders Russian professionals and policy makers less inclined to learn, while Putin's turn to nationalism enhances a sense of exceptionalism that will prove painfully self-destructive if it continues to disrupt linkages between Russian and global science.
Therefore, disrupting E6 linkage to p53 and liberating p53 in those HPV-infected cells may restore their altered biological functions and allow cells to continue the normal process of cell apoptosis.
Calpain is an attractive candidate to initiate this cytoskeletal release since cleavage of talin may disrupt the linkage between LFA-1 and actin.
We tested this hypothesis by isolating Gus1 in the presence of EDTA to disassemble ribosomal subunits and disrupt any linkage between a nascent polypeptide and its cognate mRNA.
To rule out the possibility that loads exerted by the trap might disrupt the linkage between IFT and FMG1-B, we performed TIRF imaging of IFT27-GFP and optical trapping of beads simultaneously.
Inter-chromosomal rearrangements that have occurred since the most-recent common ancestor of the prairie vole and mouse will have disrupted the physical linkage between markers resulting in orthology of a single prairie vole or mouse chromosome to two or more chromosomes in the other species.
