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In addition, disrupted interaction of BMPR2 tail domain with cytoskeletal regulator LIMK1 may contribute to the etiology of PH via regulation of actin dynamics (Foletta et al., 2003).
The other 32 mutants disrupted interaction with either Nse1 or Nse4.
This may be explained, in part, by the disrupted interaction between the IFNγ receptor and lipid rafts (Fig. 7).
Proteoglycans have been shown to undergo alterations during malignant transformation resulting in disrupted interaction between the extra cellular matrix and the transformed cells to simplify the invasion into the surrounding tissue.
Cruentaren A also disrupted interaction between Hsp90α and F1F0 ATP synthase in a dose-dependent manner.
Interestingly, we also observed that pertuzumab disrupted interaction between HER2 and IGF-IR in trastuzumab-resistant cells [ 32].
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Thus, edeine disrupted interactions between initiation complexes and the AUG mRNA.
Disrupted interactions between CA and CypA/NUP358 affect CA stability and inhibit nuclear import of the RTC.
These disrupted interactions caused the release of the functional Beclin1 and further promoted autophagy, reflecting another possible mechanism of the interactions between apoptosis and autophagy.
Ghosh, S., Nunziato, D. A. & Pitt ,G. S. KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin.
Thus, the Cys substitution severely disrupts interaction with GyrB-466.
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