They are not operating in a vacuum either, and it has been alleged that the beleaguered north Sudanese government is supplying Kony in order to disrupt newly independent South Sudan.
We thus screened over 24 000 clones, which allowed us to isolate four independent clones in which the xerC ORF was disrupted and two independent clones in which the mariner transposon had inserted within the xerC promoter, demonstrating the validity of the procedure (Supplementary Table S1).
Number of independent disrupted genes.
The murine TRIM21 gene was disrupted by two independent groups, producing markedly different phenotypes.
We do this by quantifying the extent to which certain genomic regions are disrupted repeatedly in independent lineages.
Illustrating the importance of these methodological issues, the lncRNA Fendrr has been disrupted using 2 independent strategies; although both methods resulted in a lethal phenotype, Fendrr deletion led to delayed development of the lungs (Sauvageau et al. 2013), while multisystem defects were observed after insertion of a transcriptional termination signal (Grote et al. 2013).
Trastuzumab only disrupts ligand-independent HER2 signaling; conversely, pertuzumab interferes with the formation of ligand-induced HER2 heterodimers.
One of the mechanisms of action of T is to disrupt ligand-independent HER2-HER3 heterodimer signaling [ 37].
Finally, unlike trastuzumab which only disrupts ligand-independent ERBB2 ERBB3 signaling (Junttila et al., 2009) and has no effect on ERBB1, rhPEPDG278D disrupts both ligand-independent and ligand-stimulated ERBB2 ERBB3 and ERBB1 ERBB2 interaction and signaling, and downregulates both ERBB1 and ERBB2.
Tarantino's directorial debut told the story of a diamond heist committed by suit-wearing thieves; along with 1989's Sex, Lies, and Videotape and a slew of independent films distributed by Miramax, it disrupted Hollywood, as American independent films in its wake continued to break boundaries, gain praise, and win awards.
