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Leveraging a crossover within-subjects design, we demonstrate that pivotal brain regions involved in the default mode and limbic regulatory centers have disrupted functioning following a night of restricted sleep compared to a night of "normal sleep".
28, 29 According to this suggestion, reinforced PRR activation may protect from infectious agents and prevent, inhibit, or block carcinogenesis whilst disrupted functioning of these PRRs may allow infectious agents or tumor cells to avoid recognition by the immune system and, consequently, not be eliminated.
Furthermore, disrupted functioning of the HPA axis, particularly in people who have hyperresponsive cortisol release from the adrenal cortex in response to the ACTH signal (cortisol-to-ACTH ratio as a measure of adrenal sensitivity) in the neutral relaxed state, increased the risk of alcohol relapse 2.5 times more than those with lower cortisol release from the adrenal cortex.
Their work protects the organism from infectious agents and may prevent, inhibit, or block carcinogenesis, whilst disrupted functioning of these pattern recognition receptors may allow infectious agents or tumor cells to avoid recognition by the immune system and, consequently, not be eliminated.
Some recent definitions of delusion make more explicit reference to "disrupted functioning"(e.g., McKay et al. 2005a, p. 315).
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The study, supported in part by N.I.H., involved telomeres — structures on the ends of chromosomes that shorten with age, causing disrupted function of the chromosomes.
What is most striking about their finding is the relation between disrupted function and self-feeling.
Thus, the disrupted function of interneurons due to loss of inhibitory control and increased stimulation could contribute to the cascade of events that lead to persistent chronic pain.
Guanidinylated polymers disrupted function of isolated mitochondria more than their lysine-based analogs, but overall toxicity was decreased, likely due to inefficient mitochondrial trafficking.
Disrupted function of collagen X, a major hypertrophic cartilage matrix protein, resulted in skeletal and hematopoietic defects in endochondrally derived tissues.
A Sox10 mouse mutant reduces wildtype Sox10 induction of Mitf [26], suggesting hypopigmentation in this model is due to disrupted function of Mitf.
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