Natural mutations which disrupt functionality can give insights into the roles of human genes, as can the use of gene-disrupted animal models.
An exception to this rule was made if a single PCR product was identified in the region corresponding to the C-terminal portion of the protein where a transposon insertion was considered unlikely to disrupt functionality.
It may be speculated that an abnormal ReHo may be a clue to disrupted local functionality and may provide insight into the pathophysiology of brain disorder [ 35].
Abnormal ReHo is assumed to be associated with aberrant changes in the temporal aspects of the spontaneous neural activity in the regional brain [ 14] and may be a sign of disrupted local functionality [ 15].
Some medical devices to look out for if you choose a pacemaker are: Magnetic resonance imaging (MRI) uses a powerful magnet to produce images of internal organs and functions, and can disrupt pacemaker functionality.
Because arginine is present in high abundance in the functional sites of many proteins, GO may disrupt their functionality by reducing enzymatic activity, receptor-ligand or protein-nucleotide binding.
So Apple's compact personal computer replaced IBM's ungainly behemoths thereby disrupting computer functionality through miniaturization, with many flow-on effects such as the disruptions to the music industry and the transport industry.
A barrier of this kind provides additional security for the occupants of a building without disrupting the functionality of the interior with a massive obstacle.
The device is fully waterproof, like the Oasis, although liquid on the screen can disrupt touch functionality (this is just a physics thing).
I worried, as many others have, about the negative impact of such trips -- whether these villages would face internal retaliation for working with Westerners, whether their conversion to Christianity was a facade they embraced to receive the aid, and whether such work would disrupt the functionality of their tattered economies.
These mutations are random and sufficiently rare such that they usually do not disrupt the functionality of the cell.
