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Therefore the disrupted expression of IGFBP7 by aberrantly expressed miRNAs during the gonocyte to spermatogonia transition could have implications for their growth and differentiation.
We can observe that the closest neighborhood of a significant candidate is highly differentially expressed and belongs to a more disrupted expression module than the neighborhood of a nonsignificant candidate.
In order to assess if there are any differences in gene expression between normal and abnormal karyotype hESC lines, we examined maternal expressed imprinted geneH19, paternal expressed imprinted gene IGF2 and SNRPN and conditional gene GNAS as disrupted expression of these genes is associated with human genetic diseases, such as PWS and AS.
Further, JA-deficient mutants, with a disrupted expression of OsAOC also show typical developmental phenotypes such as early flowering, elongated sterile lemma, and reduced fertility (Riemann et al. 2013).
Here we report that mice with heterozygous loss of Chd7 function exhibit delayed semicircular canal genesis, delayed Netrin1 expression and disrupted expression of genes that are critical for semicircular canal formation (Bmp2, Bmp4, Msx1 and Fgf10).
In this case the disease does not lead to detectable disrupted expression modules or affected pathways in the network.
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As a result, the insertion does not disrupt expression of the gene.
Comparative genome hybridization has identified a hemizygous duplication in this region which disrupts expression of two genes, Csrp2bp and 6330439K17Rik.
Since close proximity of the piggyBac insertion to a gene's coding sequence is more likely to disrupt expression, we repeated the functional distribution analysis on genes, whose transcription units were most likely to be disrupted by piggyBac insertion.
Does the insertion of the reporter disrupt expression?
These primers detect the inserted fragment (500 bp) that was used to disrupt expression of WNK3.
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