CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms.
We further identify a Chimaerin (CHIN-1)– Furin (KPC-1) double-mutant that severely disrupts assembly.
Panizzi, J.R. et al. CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms.
The union's departing chairman, Klaus Zwickel, accused Mr. Peters of deceiving the executive board by scheduling longer strikes that were calculated to disrupt assembly lines in western Germany.
General Motors is suing a bankrupt automotive supplier for immediate access to specialized parts and equipment, arguing that a delay would hamper the introduction of its new Chevrolet Camaro, disrupt assembly operations and cause millions of dollars in damages.
Most of the antibodies that bind to the distal 37 nm of the tail disrupt assembly of octameric minifilaments and, depending upon the exact location of the binding site, stop assembly at specific steps yielding, for example, monomers, antiparallel dimers, parallel dimers or antiparallel tetramers.
Accumulation of mutant MHC B in amounts as little as 2% of wild-type levels is sufficient to disrupt assembly of both wild-type MHC A and MHC B. Dominant unc-54 mutations occur at remarkably high frequency following ethylmethane sulfonate (EMS) mutagenesis; their frequency is approximately equal to that of recessive, loss-of-function mutations.
Therefore, excess ELL could form premature complexes with pol II prior to entering the preinitiation complex, which could disrupt assembly.
Using an in vitro tubulin polymerization assay, G-1 was found to be able to directly prevent polymerization of tubulin and disrupt assembly of microtubules.
Importantly, we emphasize that this is not an absolute rule, and that a slight majority of fusions do in fact disrupt assembly.
