Thus, he believes new neurons in the hippocampus are unlikely to disrupt old memory circuits.
A patient would recall the troubling event and be given a drug or other agent to disrupt the memory from being reconsolidated.
In contrast, LPS had no significant effect on short-term working memory performance compared to saline, while scopolamine, a cholinergic antagonist known to disrupt working memory, did impair performance.
The results showed that exposure to low doses of 56Fe particles does disrupt recognition memory and that maintaining rats on antioxidant diets containing blueberry and strawberry extract for only 2 weeks was effective in ameliorating the disruptive effects of irradiation.
The scientists' plan is to intentionally evoke alcohol-related memories in the study's participants, then disrupt the memory, and then give them either a ketamine infusion or a placebo.
For example, stereotype threat has been shown to disrupt working memory and executive function, increase arousal, increase self-consciousness about one's performance, and cause individuals to try and suppress negative thoughts as well as negative emotions such as anxiety.
The possibility that neuroactive xenobiotics such as drugs of abuse could influence or disrupt the memory function of these "footprints" as part of their neurotoxic mechanisms should merit thorough investigation.
Recent work suggests that corticosterone can, indeed, disrupt working memory [ 25], but the mechanisms by which this occurs are not known.
Previously, both 6-OHDA lesions to the mPFC and infusions of D1 antagonists have been shown to disrupt spatial memory on tasks with a delay between training and testing (Bubser & Schmidt, 1990; Seamans, Floresco, & Phillips, 1998).
It is important to note that protein synthesis inhibition in both the hippocampus and mPFC blocked the enhancement of IA memory, but did not disrupt IA memory; furthermore, mice infused with ANI to the hippocampus or mPFC displayed a comparable enhancement of IA memory at PR-LTM-2 at 48 hr after PR-LTM-1 compared to the VEH group at PR-LTM-1.
