Sentence examples for disrupt the normal tissue from inspiring English sources

Prions cause neurodegenerative disease by aggregating extracellularly within the central nervous system to form plaques known as amyloid, which disrupt the normal tissue structure.

Drusen disrupt the normal tissue architecture, disrupt function by impeding transport between the RPE and choroid, and are sites of activation of the complement system [ 11, 12].

Myofibroblasts are effector cells in SSc fibrosis, which either produce excessive fibrillar collagens in the accumulated ECMs or disrupt the normal tissue architecture, leading to the loss of organ function [1,2,9].

These changes result in a sequence of pathological events that includes impaired cell-cell communication between epithelial cells and fibroblasts, and development of fibrotic lesions that disrupt the normal tissue architecture and lead to impaired expression of the correct molecular cues and cellular mediators that maintain normal tissue structure and function.

Although short-term culture of isolated tumour cells has, in our hands, proved successful in a number of different laboratory applications [ 30- 32], it is still an imperfect model because mechanical/enzymatic disaggregation disrupts the normal tissue architecture and cell cell communications that clearly exist in vivo.

Some of these transgenic lines have already been useful to analyze early development, but comparatively they have been less effective as tools to characterize biological processes during postembryonic or larval stages, including regeneration and behavior because the early expression of Gal4-driven effector genes may disrupt the normal development of the target tissues [13], [14], [15], [16], [17].

The phenomena of neoplastic development and neoplastic transformation, whether they occur in vivo or in vitro, are thought to represent the accumulation of a series of genetic and epigenetic alterations that disrupt the normal processes of cell division and tissue integrity [1], [2], [3], [4].

They can disrupt the normal flow of society".

Such mutations disrupt the normal function of the telomerase enzyme.

We identified two mutations that disrupt the normal interaction with TRiC and impair VHL folding.

Preeclampsia can disrupt the normal growth of the fetus, leading to a preterm delivery.