Sentence examples for disrupt the normal interaction from inspiring English sources

We identified two mutations that disrupt the normal interaction with TRiC and impair VHL folding.

We examine the potential cellular and molecular mechanisms by which a viral infection of the placenta might disrupt the normal interaction between the cellular component of the implantation site and bacteria.

Recessive resistance of peppers to potyvirus depends on the substitution of relevant amino acid residues in eIF4E that disrupt the normal interaction between this translation factor and VPg.

Bcr-Abl induces p130Cas phosphorylation and its constitutive binding to CrkL, disrupting the normal interaction between p130Cas and tensin [ 12].

Moreover, during the development of the peripheral nervous system in mammals, it is known that disrupting the normal interactions between motor axon and SCPs (Schwann cell progenitors) leads to abnormal motor axon growth, pathfinding, fasciculation and muscle innervations (Riethmacher et al., 1997; Morris et al., 1999; Woldeyesus et al., 1999).

Perhaps upregulation of SBP2 family genes and subsequent overexpression of the proteins disrupt the normal matrix of protein-protein interaction, resulting in virulence loss.

It thus appears reasonable to suggest that the interaction of the novel THIQ derivative 9c can at least partially be ascribed to its ability to disrupt the normal dynamic polymerization of tubulin by interaction at, or around, the colchicine site.

It is thus reasonable to suggest that the activity of the novel DHIQ derivatives can at least partially be ascribed to their ability to disrupt the normal dynamic polymerisation of tubulin by interaction at, or around, the colchicine binding site (Table 4).

It takes place in the crowded internal environment of the cell, where many intermolecular interactions could potentially disrupt the normal protein folding pathway.

OA can result from the dysregulation of a complex set of biomechanical and biochemical interactions between multiple structures, which can disrupt the normal homeostasis of the joint (Loeser et al., 2012; Lories, 2011).

Venom C-type lectin related proteins are known to disrupt the normal functioning of haemostatic mechanism by interfering in the normal platelet receptor-ligand interaction, binding to coagulation factors and other important proteins in coagulation cascade [ 48].