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One mechanism is through disruption of gene function: microsatellite expansions residing in exon or intron sequences disrupt the normal function of the gene product.
Such mutations disrupt the normal function of the telomerase enzyme.
Mechanical loading as a result of accident or any kind of trauma can disrupt the normal function of the kidney.
Chronic muscle disease and muscle ageing disrupt the normal function of myeloid cells, FAP cells and Treg cells, which can lead to impaired muscle regeneration and increased muscle fibrosis.
At prolonged incubation times, radiation-induced stress and other toxicity effects of 125I]SGMIB-MNT could disrupt the normal function of NLS-mediated nuclear import [28].
Therapies that help the human immune system recognize, home in on and disrupt the normal function of cancer cells rely on monoclonal antibodies — cloned armies of genetically engineered molecules that mimic the function of immune cells.
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This has continued to disrupt the normal functioning of the government throughout its tenure.
The results indicated that nanoparticles caused damage to cells by producing pits in the outer cell wall which disrupt the normal functioning of the bacteria [34].
Dioxin is a known carcinogen and can disrupt the normal functioning of hormones, as well as immune, nerve and reproductive cells.
Protein nitrotyrosylation may disrupt the normal functions of mesangial cells and the kidney, leading to abnormalities in the structure and/or function of diabetic kidney.
Upon accumulation, Aβ was reported to disrupt the normal functioning of neurons resulting in significant cellular dysfunction leading to apoptosis [6] and oxidative injury [7], even before the formation of senile plaques and neurofibrillary tangles.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com