Sentence examples for disrupt the interactions from inspiring English sources

Herein, our attempts are focused on the discovery of novel small molecules that can compete to bind with one of the interacting proteins with higher binding affinity in order to disrupt the interactions between APP and BACE-1 and simultaneously are able to bind to the PAS site of AChE.

These three mutants seem to share similar consequences: they all disrupt the interactions in the homotrimer and therefore result in the inability of EDA to interact with its target receptors.

A synthetic peptide, P6-55, that contains the N-terminus of PAQR3 could disrupt the interactions of p110α with both PAQR3 and p85.

One approach to treat these diseases consists of finding drug candidates able to disrupt the interactions established between BCL6 and its corepressors.

Missense mutations that fall on interfaces and nonsense/frameshift mutations that result in truncated negative regulators disrupt the interactions with the targets, thereby enabling constitutive activation of the nuclear factor-kappa B, and contributing to chronic inflammation, autoimmune diseases, and oncogenesis.

In this study, A101 was indicated to inhibit or disrupt the interactions of cell-surfaces and cell-cell.

Another possibility is that obacunone can disrupt the interaction between Nrf2 and Keap1, leading to the stabilization of Nrf2.

In particular, PAH could disrupt the interaction of Tat peptide with TAR RNA, which is critical for HIV-1 virus replication.

Gabapentin has been shown to disrupt the interaction of thrombospondin (TSP) with α2δ-1, auxiliaryary calcium channel subunit.

Compounds which disrupt the interaction between TAZ-TEADs are considered as good candidates for inhibition of the oncogenic roles of TAZ (Sudol et al., 2012).

The addition of ouabain (10 µM) to preformed ATP1A1-PKCη complexes did not disrupt the interaction.