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Each of the above reactions, however, can disrupt the functional homeostasis of vital organs including the lungs, heart, liver and kidney [2].
To disrupt the functional murine Pold1 protein, we inserted a splice/polyadenylation (poly(A)) signal derived from SV40 into the upstream region encoding the Polδ polymerase domain (schematic in Fig. 1A).
To investigate whether the tissue-specific A-to-I editing may disrupt the functional elements of ESE and ESS, we analyzed the edited and unedited exon sequences with the EditFunc web server using the programs ESEfinder [34] [35] and FAS-ESS [36].
The formation of immune complexes and their accumulation in electron-dense deposits disrupt the functional integrity of the glomerular filtration barrier by a complement-dependent process.
A frameshift mutation was identified in the REase gene upstream of the MTase and this may disrupt the functional expression of the MTase if it is transcribed as an operon.
Changes in tumor cells' physical and material properties that disrupt the functional modules required for metastasis could provide a much broader treatment option which is not limited to few solid tumors.
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For example, a recent study of smokers trying to quit showed how mindfulness disrupts the functional connectivity of the craving network in the brain.
Chondrosarcomas were established in explant cultures, and treated with choral hydrate, which disrupts the functional primary cilia.
This means, roughly, that it should be physically possible to intervene on a putative cause variable in a mechanism without disrupting the functional relationships among the other variables in the mechanism.
We investigated whether inhibition of the Src kinase signalling network could have a role in disrupting the functional interaction between HOXC11 and SRC-1 in melanoma cells.
Similarly, since the only occurrence of τ is in ratio with d k (i ), a correction for the beam waist can be applied as a d scaling factor on τ without disrupting the functional form of the underlying data.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com