Similarly, a ~4.4 Kb stretch of TE insertions in the coiled-coil encoding region of the CqLRIM2A paralogue may disrupt the function of this copy, leaving CqLRIM2B as the likely functional APL1/LRIM2 orthologue.
T cell epitopes within funtional domains would remain conserved over time as viral mutations useful towards immune escape may disrupt the function of the domains and affect viral fitness unless compensated functionally by multiple co-mutations [49], [50].
The abnormal gene is able to disrupt the function of the normal gene, causing disease.
Oxidative stress, hypoxia and calcium imbalance also disrupt the function of Krebs cycle in AD brains.
Enzymes in the body also contain sulfur and if arsenic bonds at these atoms it can disrupt the function of the enzyme.
These differences could be exploited in the discovery of reagents which selectively disrupt the function of FhGAPDH.
To test this hypothesis, we used two different methods to disrupt the function of the single bone-specific SIBLING gene spp1 in zebrafish.
This is driven by evolutionary changes to the DNA underlying these traits, frequently via the accumulation of mutations that disrupt the function of a formerly useful locus.
The problem with drug addiction is that it does have a physical basis, where foreign elements introduced into the body disrupt the function of certain organs, in this case the brain.
The monopolar "Bovie" instrument emits radiofrequency energy that can disrupt the function of other implanted electronic devices through a phenomenon termed electromagnetic interference.
Considering the nature of NATs and the fact that many currently available drugs would not affect the activity of non-coding RNA molecules, developing new methods to disrupt the function of NATs seems necessary.
