Sentence examples for disrupt the expression from inspiring English sources

Gene fusions in cancer typically lead to the expression of a fusion protein or disrupt the expression of one of the parental genes.

The lead compounds, JG243 and JG244, which form an intramolecular parallel G-quartet structure, selectively target HIF-1α HIF-1αcreanddecreasedof both HIF-1α and HIF-2α (IC50 < 2 µmolevelsnd alsofinhibothd the expression of HIF-1αregulated proteins [vascular endothelial growth factor (VEGF), Bcl-2, and Bcl-XL], but did not disrupt the expression of p300, Stat3, or p53.

We further investigated the role of ACSL4 using small hairpin RNA (shRNA) to disrupt the expression of endogenous ACSL4 in the more aggressive cell line MD-MB-231.

To confirm this apparent functional redundancy between these two kinases in the circadian system, it would be ideal to use a genetic approach to simultaneously disrupt the expression of both CK1δ and CK1ε.

When genetic techniques are used to disrupt the expression of follistatin, regeneration is completely blocked.

The fruΔ A and fruΔ B mutant alleles also disrupt the expression of the non-sex-specific (common) FruA and FruB isoforms.

Both regimens of E2 disrupted the expression of spatial memory in place-learners following the novel start position.

This so-called microRNA disrupts the expression of two key cellular genes called TGF-β and SMAD3, in a process known as RNA interference (RNAi).

In Drosophila, disrupting the expression levels of chico, a mammalian IRS homology, resulted in enhanced immune function, improved behavior, and extended lifespan (Martin and Grotewiel, 2006; Libert et al., 2008).

Our data indicated that in Japanese rice fish, ethanol disrupted the expression of only cnr1a in a concentration-dependent manner that induced delay in hatching and might be responsible for the development of FASD phenotypes.

Dale's team is also looking at how gene insertion itself may alter transgenic plants, for example by disrupting the expression of endogenous plant genes close to the location of the insertion.